Product Description of 4-(1-Acetylpiperazin-4-yl)phenol CAS#67914-60-7
4-(1-Acetylpiperazin-4-yl)phenol, alternatively referred to as 1-Acetyl-4-(4-hydroxyphenyl)piperazine, is a core intermediate for pharmaceutical synthesis. It is mainly applied in the preparation of antifungal drugs and antipsychotic pharmaceutical ingredients.
This chemical substance presents as a white to off-white crystalline powder in its standard form. According to literature data, it delivers a melting point of 180–185°C and a theoretical boiling point of 361.21°C. Its stable thermal properties render it adaptable for a wide range of pharmaceutical synthetic procedures.
4-(1-Acetylpiperazin-4-yl)phenol Chemical Properties
| Melting point | 180-185 °C (lit.) |
| Boiling point | 361.21°C (rough estimate) |
| density | 1.1115 (rough estimate) |
| vapor pressure | 0Pa at 20℃ |
| refractive index | 1.6000 (estimate) |
| storage temp. | -20°C Freezer |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Powder |
| pka | 12.18±0.30(Predicted) |
| color | White to slightly pink or beige |
| Water Solubility | 4.3 g/L (20 ºC) |
| BRN | 795777 |
| InChIKey | AGVNLFCRZULMKK-UHFFFAOYSA-N |
| LogP | 0.3 |
| CAS DataBase Reference | 67914-60-7(CAS DataBase Reference) |
| Hazard Codes | Xi,Xn |
| Risk Statements | 36/37/38-22 |
| Safety Statements | 26-36-36/37/39-22 |
| WGK Germany | 3 |
| HS Code | 29214910 |
Product Application of 4-(1-Acetylpiperazin-4-yl)phenol CAS#67914-60-7
This substance works as an indispensable medicinal synthetic intermediate, which gets extensively adopted for mass-producing antifungal preparations and psycho-active medicines.
Manufacture of antifungal pharmaceuticals：It acts as a vital side-chain precursor for famous anti-fungal substances including ketoconazole and itraconazole, assisting the assembly of their fundamental molecular skeletons.
Preparation of antipsychotic medicines：Apart from antifungal production, the compound participates in synthesizing the atypical antipsychotic aripiprazole to construct indispensable segments of the drug framework.
Raw material for pharmaceutical exploration：Equipped with phenolic-hydroxyl and piperazine functional groups, the chemical owns favourable reaction activity. Researchers take advantage of it to create multiple bio-active substances, such as serotonin receptor binders and prospective drug compounds.
